Table 2 Major differences between cervical cancer and HPV-associated OPSCC
| OPSCC | Cervical Cancer | |
|---|---|---|
| Incidence | Incidence increasing | Incidence decreasing |
| Prevalence | Increased in higher-income countries | Increased in lower-income countries |
| Sex | > 70% male | 100% female |
| Etiology | Tobacco and alcohol remain important causes, along with HPV | Virtually all are caused by HPV |
| HPV genotype |
> 95% HPV16 HPV18 rare |
50% HPV16 20% HPV18 |
| Premalignant lesions | Unknown | CIN1–3 |
| Screening tests available | No | Yes |
| 5-year survival rate | > 75% | < 70% |
| TRAF3/CYLD mutations | Approximately 30% | Rare |
| Treatment sensitivity to chemotherapy and radiation | High | Moderate |